DIG-AI

Deciphering plant genotype-phenotype Interactions using knowledge Graphs and AI

Alliance of genetics and artificial intelligence for agriculture in the South

The objective of this new project is to use artificial intelligence to help agriculture in developing countries adapt to climate change. In a context of climate change, farmers no longer have the time to carry out traditional breeding. The contribution of artificial intelligence will make it possible to understand the links between the plant genome and its adaptability in order to identify key genes.

Agriculture in the South faces challenges

Growing food demand, the need for new varieties adapted to climate change, and the search for innovative solutions are some of the challenges facing developing countries. Many of the expected improvements depend on a detailed knowledge of the genetic potential of cultivated plants. In a living being, the set of genes (= genotype) is translated into morphological characteristics (= phenotype) that are more or less adapted to environmental parameters (natural and cultivated). "A better understanding of the relationships between genotype and phenotype is one of the crucial areas of research in agronomy," explains Pierre Larmande, coordinator of DIG-AI. However, the masses of biological data, which are often heterogeneous, incomplete and from different scales of observation, must be integrated into a representation of the entire biological system. This is where artificial intelligence comes in.

Data integration and hypothesis generation

"Recent advances in high-throughput technologies have led to an explosion in the amount of data in the agronomic field," he adds. There is an urgent need to effectively integrate complementary information to understand the biological system as a whole." Indeed, for scientists, locating relevant information in these mountains of data is sometimes like looking for a needle in a haystack... The researchers from the DIADE and LIRMM Units plan to develop original approaches using artificial intelligence to integrate, enrich and analyze biological data with the aim of predicting key genes, as well as their regulatory networks, for agronomic traits of interest. They have already developed AgroLD, a knowledge base for the study of the phenome? of cultivated plants. With a hundred or so data sets from 15 public sources and concerning 12 tropical crop species, it will of course be at the heart of DIG-AI. This powerful tool is based on Semantic Web? technology and relevant biological ontologies? It will facilitate the formulation of new scientific hypotheses linking genotype and phenotype.

Answering critical questions

What are the key genes for plant adaptation to climate change? How do these genes interact with each other to determine phenotype expression? The DIG-AI members aim to understand how the biological system works. "The difficulty is to identify these interactions, which exist at different molecular levels in the plant and are strongly influenced by environmental factors," explain the resarchers in the proposal. By answering these essential questions, DIG-AI will contribute to achieving two of the Sustainable Development Goals: MDG 2 "Eradicate hunger, ensure food security" and MDG 15 "Conserve and restore terrestrial ecosystems".

Teams

IRD UMR DIADE
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Bill HAPPI

PhD student in computer science

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Pierre LARMANDE

Researcher in computer science, specialized in bioinformatics, data integration and Knowledge Grahs.

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Mikael LUCAS

Researcher in bioinformatics, specialized in modeling gene regulatory networks.

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Pascal GANTET

Professor in Plant Biology, specialized in root architecture plasticity.

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Antony CHAMPION

Researcher in plant Biology, specialized in plant response to biotic stress and root architecture plasticity.

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Alexandre GRONDIN

Researcher in Plant Biology, specialized in plant reponse to drought stress.

LIRMM
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Jerome AZE

Professor in computer science, specialized in data mining, machine learning and representation learning.

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Konstantin TODOROV

Assistant Professor in computer science, specialized in Knowledge Graphs, machine learning and representation learning.

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Francois Scharffe

Assistant Professor in computer science, specialized in Knowledge Graphs, ontology matching and representation learning.

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Antoine TOFFANO

PhD student in computer science

Adresses of labs

IRD / UMR / DIADE
LIRMM / ADVANSE

News & Events

Publications

The objective of this new project is to use artificial intelligence to help agriculture in developing countries adapt to climate change. In a context of climate change, farmers no longer have the time to carry out traditional breeding. The contribution of artificial intelligence will make it possible to understand the links between the plant genome and its adaptability in order to identify key genes.

DLinker Results for OAEI 2022
Happi Bill Gates, Géraud Fokou Pelap, Danai Symeonidou, Pierre Larmande.

17th International Workshop on Ontology Matching, OM 2022, Oct 2022, Online, France. pp.166-173.

Paper link Hal Link